However, the choice of molecular markers according to the purpose is crucial viz. Molecular markers, which reveal polymorphisms at the DNA level are now a days key players in animal genetics. The results of current study contributed to a better understanding of genes influencing growth and body conformation traits in goat. Moreover, pleiotropic effects were observed for some SNPs for body weight and conformation traits. The functional aspects of these candidate genes suggested their potential role in body growth. We have identified a number of highly significant SNPs and respective candidate genes associated with growth and body conformation traits. Genes were annotated from Capra hircus genome using assembly ARS1. Linear mixed model was used for the association study.
Association of genotypic data with the phenotypic data was performed using Plink 1.9 software. Genomic DNA was extracted and genotyped using 50 K SNP bead chip. Blood samples were collected from 879 unrelated animals of seven goat breeds along with data for body weight and morphometric measurements including body length, body height, pubic bone length, heart girth and chest length. Therefore, we performed GWAS using 50 K SNP Chip for growth in term of age adjusted body weight and morphometric measurements in order to identify genomic regions influencing these traits among Punjab goat breeds. There is paucity of literature on GWAS for economically important traits i.e., body weight and morphometric measurements. Punjab province has 37% of country’s total population with seven important documented goat breeds namely Beetal, Daira Din Pannah, Nachi, Barbari, Teddi, Pahari and Pothwari. Pakistan is third largest country in term of goat population with distinct characteristics of breeds and estimated population of 78.2 million.
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